AEG resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics. While XIAP-deficient HCT cells retained some sensitivity to AEG to external apoptotic. Figure 4. Processing and down-regulation of c-FLIP in Panc1 cells in response to SMC-AEG and TNFa. Panc1 (A), ACP (B), A (C), and U (D) cells were treated with a vehicle or nmol/L SMC-AEG for 24 h, and then these cells were exposed to ng/mL TNFa. At the indicated times, cells were harvested and subjected to Western . View and Download AEG instruction manual online. PDF User Guide.
Ariston LL 69 Manuals User Guides. User Manuals, Guides and Specifications for your Ariston LL 69 Dishwasher. Database contains 1 Ariston LL 69 Manuals (available for free online viewing or downloading in PDF): Instruction booklet. AEGµM RESVµM RESVµM No Treatment RESVµM RESVµM A: PMA-differentiated U 0 2 4 6 8 10 12 14 16 18 20 24 26 28 30 32 36 38 40 42 44 46 48 Number of Red Objects (Dead Cells)/mm 2 Hours of Treatments AEGµM RESVµM RESVµM No Treatment RESVµM RESVµM B. AEG is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination.
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